Another lab paper demonstrates systemic toxicity of PM. Inhalation tox was not available online, so the Dodger can figure the number of particles in the 0.3 u range in the PM 2.5, and therefore a gram to gram extrapolation from this experiment is not appropriate.
Rats were treated using PM2.5 at different dosages (1.5, 7.5, 37.5 mg/kg). Rats were sacrificed 24 h after one-time intratracheal instillation. PM2.5 at dosages of 7.5 and 37.5 mg/kg significantly increased lipid peroxidation levels in the hearts, livers, lungs, and testicles, decreased SOD, CAT, and GPx activities in the lungs, livers, kidneys, and brains, and depleted GSH levels in all the measured organs compared to the control. These results led to a conclusion that airborne PM2.5 was a systemic toxic agent, not only to respiratory and cardiovascular systems. Its toxic effects might be attributed to oxidative damage mediated by prooxidant/antioxidant imbalance or excess free radicals.
Inhalation Toxicology Volume 17, Number 9 / August 2005
Pages: 467 - 473
Effects of Airborne Fine Particulate Matter on Antioxidant Capacity and Lipid Peroxidation in Multiple Organs of Rats
Xiaoli Liu A1 and Ziqiang Meng A1
A1 Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan, China
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