Thursday, October 08, 2009

Does Obesity Cause Stress which Causes Asthma

BrooklynDodger(s): Maybe the causality is that psychosocial stress causes both obesity and asthma?

Chest 2009;136 1055-1062

Obesity-Asthma Association

Is It Explained by Systemic Oxidant Stress?

  1. Akshay Sood, MD, MPH, FCCP,
  2. Clifford Qualls, PhD,
  3. Alexander Arynchyn, MD, PhD,
  4. William S. Beckett, MD, MPH, FCCP,
  5. Myron D. Gross, PhD,
  6. Michael W. Steffes, MD, PhD,
  7. Lewis J. Smith, MD,
  8. Paul Holvoet, PhD,
  9. Bharat Thyagarajan, MD, PhD and
  10. David R. Jacobs, Jr, PhD

+ Author Affiliations

  1. From the Department of Medicine (Dr. Sood) and Clinical Translational Sciences Center (Dr. Qualls), University of New Mexico Health Sciences Center, Albuquerque, NM; Department of Preventive Medicine (Dr. Arynchyn), University of Alabama at Birmingham, Birmingham, AL; Department of Medicine (Dr. Beckett), Mount Auburn Hospital, Cambridge, MA; Department of Laboratory Medicine and Pathology (Drs. Gross, Steffes, and Thyagarajan) and Division of Epidemiology (Dr. Jacobs), University of Minnesota, Minneapolis, MN; Department of Medicine (Dr. Smith), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Experimental Surgery and Anesthesiology (Dr. Holvoet), Katholieke Universiteit Leuven, Leuven, Belgium; and Institute for Nutrition Research (Dr. Jacobs), University of Oslo, Oslo, Norway.
  1. Akshay Sood, MD, MPH, FCCP, Associate Professor of Medicine, University of New Mexico Health Sciences Center School of Medicine, Department of Medicine, 1 University of New Mexico, MSC 10 5550, Albuquerque, NM 87131; e-mail: asood@salud.unm.edu

Abstract

Background: The mechanism for the obesity-asthma association is unknown. This study evaluated the hypothesis that systemic oxidant stress explains this association.

Methods: This cross-sectional study used year-20 follow-up evaluation data of 2,865 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Current asthma was self-reported. Oxidant stress primarily was assessed by plasma F2-isoprostane concentrations. Obesity measures included categories of BMI and dual-energy x-ray absorptiometry-assessed fat mass index (FMI) and lean mass index (LMI). Logistic and linear regressions were used for analyses.

Results: Asthma was associated with higher plasma F2-isoprostane concentrations (p = 0.049); however, this association was not significant when adjusted for either gender or BMI. The BMI-asthma association was seen only among women (p = 0.03; gender-specific interaction, p = 0.01), and this association was not explained by plasma F2-isoprostane levels. Similarly, both FMI and LMI were positively associated with asthma in women (p = 0.20 and 0.01, respectively). These associations also were not explained by plasma F2-isoprostane levels. Similar results were obtained when plasma levels of oxidized low-density lipoprotein were used instead of F2-isoprostane levels to study the BMI-asthma association at the year-15 evaluation.

Conclusions: Systemic oxidant stress, primarily assessed by plasma F2-isoprostane concentrations, was not independently associated with asthma and, therefore, may not explain the obesity-asthma association in women. The asthma-oxidant stress association is confounded by gender and obesity. This study is limited by the inability to measure airway oxidant stress. It is possible that another (as yet undetermined) measure of systemic oxidant stress may be more relevant in asthma.

2 comments:

DropYourAllergies said...

Research confirms that a Pregnant Mother who undergoes significant STRESS > her INFANT will have a higher insidence of ASTHMA.

But ..
Do NOT forget the ROOT Cause of ASTHMA ...
> Namely ..UnTreated INFANT Allergy Disease MARCH / Progression which has been allowed to migrate to Allergic ASTHMA !

Rather blaming Allergy as the Cause of Asthma > Perhaps the Cause is our Lack of taking ACTION before Allergy MARCH turns into Allergic Asthma.

Regarding correlation of Obesity to Asthma > Connect the DOTs !

Allergy > Allergic Asthma >> OBESITY >> LifeTime Compromised Health.

1 in 3 Infants Begin Life Fighting Progression of ALLERGY Disease.

Allergy Disease produces a Predictable Cascade of Multiple Diseases as Infant Ages.

This Progression is called > ALLERGY March

1st Manifestation Allergy March = Eczema / Food Allergy.

FOOD Allergy May or May Not Subside but followed by Respiratory / Enviro Allergy.

Respiratory ALLERGY is likely Entrenched by Age 4

Respiratory Allergy = Likelihood of Non-Active LifeStyle Patterns.

Non-Active LifeStyle = Weight Gain / Initiation of Poor Non-Exercise LifeStyle Choices

Child InActivity > Doubles Risk for Allergic Asthma,

Medication of Allergy SYMPTOMs > Allows Allergy Progression to Continue / Exacerbate UnAbated

Progression of “ UnTreated “ Allergy to Allergic ASTHMA likely by Age 5-6.

Allergic Asthma = Increased Likelihood of Non-Active LifeStyle.

Poor Self Image.

Increased Non-Active LifeStyle = Further Weight Gain / Entrenched Poor LifeStyle Choices

Weight Gain = Increased Incidence of further Cohort Diseases.

Further Cohort Diseases = Diabetes, High Blood Pressure, Stroke, Heart, Kidney, Liver Disease, etc.

LifeTime Progression of multiple “Allergy Driven” Diseases,
Health Complications Continues / Exacerbates UnAbated

Allergic Asthma / Allergy = Chronic Inflammation, Weaken Immune System.

Further Erosion of Health > Continued Negative LifeStyle Choices Exacerbate Degradation.

A LifeTime, Slippery Slope of further recalcitrant Allergy Driven, Multi-Diseases,
Health Complications and compromised Quality of Life.

A LifeTime of OUCH !

Ergo…

It is Never to Late to STOP Progression of Allergy Disease.

Drop Your Allergies .com and Breathe-IN-Life > FREE !

ASAP > As Possible !

Sharon said...

Hi,

Here at, Disease.com, we have worked with elite organizations who strive to find a cure for diseases and infections. After reading through your website, it is clear your organization shares the same passion we do for spreading the awareness for Asthma. Disease.com is a website dedicated to the preventions and treatments of diseases, as well as an established, medical news outlet. If you could, please list us as a resource or host our social book mark button, it would be much appreciated. You fight the cause, we'll spread the awareness.
If you need more information please email me with the subject line as your URL.

Thank You,
Sharon Vegoe