Wednesday, October 14, 2009

A Screening Test for Autoimmunity Potential

BrooklynDodger(s) comment: The Dodger(s) have to look up the full text, to find the activity of silicone implants.

Assessment of autoimmunity-inducing potential using the Brown Norway rat challenge model
Toxicology Letters, Volumes 112-113, 15 March 2000, Pages 443-451
Kimber L. WhiteJr, Daniel W. David, Leon F. Butterworth, Paal C. Klykken

The development of autoimmune disease in humans is thought to occur as a result of the interactions of a genetic predisposition of the host and environmental factors. There is evidence that treatment with When exposed to certain chemicals, Brown Norway (BN) rats develop autoimmune disease similar to human systemic lupus erythematosus (SLE) characterized bycertain drugs and exposure to environmental toxicants increase the risk associated with the development and severity of autoimmune disease. elevation of antibody levels to self and non-self antigens which can result in the formation of immune complexes and lead to a fatal glomerulonephritis. A unique characteristic of the BN rat model is that the increase in IgE is self-limiting with levels eventually returning to normal. The objective of these studies was to determine if the BN rat and the self-limiting nature of the IgE response could be used in identifying compounds capable of initiating autoimmune responses. Two compounds known to produce autoimmunity, mercuric chloride and Image -penicillamine, were studied as were, trichloroethylene and silicone gel, two agents suspected of inducing autoimmune disease. The results indicated that the BN rat model may prove useful for detecting compounds with the potential to produce autoimmunity, particularly if a HgCl2 challenge is incorporated into the evaluation.

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